| Dr Eric Kmiec Helen F. Graham Cancer Center & Research Institute Christiana Care Health System | 4 | Dr Eric Kmiec Helen F. Graham Cancer Center & Research Institute Christiana Care Health System | Ewing 336 | Title:CRISPR-directed Human Gene Editing: Clinical Application for
Sickle Cell Disease</br></br>
Abstract: TBA | 2/21/2018 7:30:00 PM | 2/21/2018 8:20:00 PM | | |
| Dr Ashutosh Khandha, Delaware Rehabilitation Institute, UD | 6 | Dr Ashutosh Khandha, Delaware Rehabilitation Institute, UD | EWG 336 | Title: Title: Knee biomechanical and biochemical variables early after anterior
cruciate ligament reconstruction - mathematical modeling and experimentation
<br></br>
Abstract: Premature knee osteoarthritis (OA) after anterior cruciate ligament
reconstruction (ACLR) is a growing concern in a young population. 30 %
of subjects with ACLR have radiographic knee OA 5 years after surgery.
Using experimental gait analysis and electromyography-informed
mathematical neuromusculoskeletal modeling, we have seen that those with
OA at 5 years can show inter-limb differences in “biomechanical” knee
gait variables (joint loading and kinematics) as early as 6 months after
surgery. Also, quantitative magnetic resonance imaging (qMRI) has the
potential to detect “biochemical” OA related changes in the knee
cartilage, earlier than radiographs. High values of cartilage T2
relaxation time, a qMRI time constant, can indicate early OA onset
changes (collagen matrix degradation). Currently, it is not known
whether both inter-limb differences in knee gait variables as well as
cartilage T2 values are present as early as 3 months after ACLR. As the
first step of a longitudinal study, we investigated these biomechanical
and biochemical variables in 15 subjects, at both 3 and 6 months after
ACLR. The overall goal of the study is to evaluate the changes in these
variables over time (up to 2 years after ACLR) and to evaluate how soon
can OA related changes be detected. The sooner the detection, the
greater the potential for intervention to delay OA progression. | 11/15/2017 7:30:00 PM | 11/15/2017 8:20:00 PM | | |
| Vu Dinh | 3 | Vu Dinh | | | 9/27/2017 6:30:00 PM | 9/27/2017 7:20:00 PM | | |
| Rebecca Sanft (University of North Carolina at Asheville) | 1 | Rebecca Sanft (University of North Carolina at Asheville) | EWG 336 | Title: Modeling the Mechanical Response of Arteries
Abstract: Unlike traditional engineering materials, arterial tissue
exhibits anisotropic and highly nonlinear mechanical behavior, and it
displays the fascinating ability to grow and adapt to a given mechanical
environment. This talk aims to provide an overview of the theoretical
framework for modeling the mechanical response of arteries that reflects
aspects of the fiber structure, muscle contraction, and growth. Moreover,
we will discuss mathematical tools that can help us understand and predict
alterations such as buckling and folding in arterial morphology. | 9/20/2017 6:30:00 PM | 9/20/2017 7:20:00 PM | | |
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