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Applied Mathematics and Mathematical Medicine and Biology

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Applied Mathematics and Biology Seminars are held Wednesdays, 11:15am - 12:15pm in Ewing 336. 

Want to suggest a speaker? Send an email to one of the organizers: Pak-Wing Fok or Richard Braun.

Information about the Courtyard Newark - University of Delaware Hotel



Dr Eric Kmiec, Helen F. Graham Cancer Center & Research Institute, Christiana Care Health SystemDr Eric Kmiec, Helen F. Graham Cancer Center & Research Institute, Christiana Care Health SystemEwing 336Title: CRISPR-directed Human Gene Editing: Clinical Application for Sickle Cell Disease <br></br> Abstract: The capacity to genetically modify a human chromosome has increased significantly with the introduction of programmable nucleases, including Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and Cas9/Cpf1 Nucleases. CRISPR-directed gene editing of human cells is revolutionizing the treatment of inherited diseases including Sickle Cell Disease (SCD). This seminar will outline the clinical and developmental program aimed at repairing the mutation in SCD patient cells currently taking place at the Gene Editing Institute at Christiana Care Health System. In addition, the novel clinical approach for treating non-small cell lung cancer (NSCLC), using CRISPR-directed gene editing to disable functionally key genes responsible for chemo-resistance in humans being carried out at the same institution, will also be discussed. 2/21/2018 4:15:00 PM2/21/2018 5:15:00 PMFalse
Drew LaMar, College of William and MaryDrew LaMar, College of William and MaryTitle: Data-driven modeling in ecology: A case-study in research, education, and professional development <br></br> Abstract: The monarch butterfly, the "king of the butterflies," was recently added to the endangered species list in 2016. Their numbers have dropped over 80% in the past decade, in large part to the synchronous drop in *Asclepias syriaca*, or common milkweed, which is the monarch's sole food source while in their larval state. In this talk, I will introduce an integral projection model that is used to explore the possible effects and sensitivity of herbivory on population growth of milkweed. Integral projection models are fantastic examples of models that have strong connections with real-world data, utilizing ideas from calculus, linear algebra and statistics. I will also discuss the importance of reproducibility in research, specifically as it pertains to data cleaning and modeling scripts, and how open-source software development and dissemination is an underappreciated and highly important aspect of the scientific enterprise. 2/27/2018 4:15:00 PM2/27/2018 5:15:00 PMFalse

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  • Department of Mathematical Sciences
  • University of Delaware
  • 501 Ewing Hall
  • Newark, DE 19716, USA
  • Phone: 302-831-2653